Conformational Dynamics Accompanying the Proteolytic Degradation of Trimeric Collagen I by Collagenases
نویسندگان
چکیده
منابع مشابه
Conformational dynamics accompanying the proteolytic degradation of trimeric collagen I by collagenases.
Collagenases are the principal enzymes responsible for the degradation of collagens during embryonic development, wound healing, and cancer metastasis. However, the mechanism by which these enzymes disrupt the highly chemically and structurally stable collagen triple helix remains incompletely understood. We used a single-molecule magnetic tweezers assay to characterize the cleavage of heterotr...
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ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2012
ISSN: 0002-7863,1520-5126
DOI: 10.1021/ja212170b